The girls used a flexible plastic ring, embedded with anti-retroviral drugs, which was changed every month over a six-month period.
It's part of a drive to develop a device which women can use to protect themselves from HIV infection, so they don't have to rely on men to wear condoms.
Reporting the development at a conference about HIV science in Paris, the researchers said they were encouraged that the girls used the ring and said they liked it.
Women and girls aged 15-24 account for a fifth of all new HIV infections globally.
Nearly 1,000 are infected every day in sub-Saharan Africa.
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